イワサキ　マサユキ   Iwasaki Masayuki   岩崎　正幸    所属   研究施設 研究施設    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Epigenetic roles of MLL oncoproteins are dependent on NF-κB.
掲載誌名	正式名：Cancer cell 略　 称：Cancer Cell ISSNコード：18783686/15356108
掲載区分	国外
巻・号・頁	24(4),pp.423-37
著者・共著者	Kuo Hsu-Ping, Wang Zhong, Lee Dung-Fang, Iwasaki Masayuki, Duque-Afonso Jesus, Wong Stephen H K, Lin Chiou-Hong, Figueroa Maria E, Su Jie, Lemischka Ihor R, Cleary Michael L
発行年月	2013/10
概要	MLL fusion proteins in leukemia induce aberrant transcriptional elongation and associated chromatin perturbations; however, the upstream signaling pathways and activators that recruit or retain MLL oncoproteins at initiated promoters are unknown. Through functional and comparative genomic studies, we identified an essential role for NF-κB signaling in MLL leukemia. Suppression of NF-κB led to robust antileukemia effects that phenocopied loss of functional MLL oncoprotein or associated epigenetic cofactors. The NF-κB subunit RELA occupies promoter regions of crucial MLL target genes and sustains the MLL-dependent leukemia stem cell program. IKK/NF-κB signaling is required for wild-type and fusion MLL protein retention and maintenance of associated histone modifications, providing a molecular rationale for enhanced efficacy in therapeutic targeting of this pathway in MLL leukemias.
DOI	10.1016/j.ccr.2013.08.019
PMID	24054986