イワサキ　マサユキ   IWASAKI Masayuki   岩崎　正幸    所属   研究施設 研究施設    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis.
掲載誌名	正式名：Cancer cell 略　 称：Cancer Cell ISSNコード：18783686/15356108
掲載区分	国外
巻・号・頁	17(6),pp.597-608
著者・共著者	Wang Zhong, Iwasaki Masayuki, Ficara Francesca, Lin Chenwei, Matheny Christina, Wong Stephen H K, Smith Kevin S, Cleary Michael L
担当区分	2nd著者
発行年月	2010/06
概要	Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias.
DOI	10.1016/j.ccr.2010.04.024
PMID	20541704