クマキリ　ジユン   Kumakiri Jiyun   熊切　順    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Adhesion-prevention effects of fibrin sealants after laparoscopic myomectomy as determined by second-look laparoscopy: a prospective, randomized, controlled study.
掲載誌名	正式名：The Journal of reproductive medicine 略　 称：J Reprod Med ISSNコード：00247758/00247758
掲載区分	国外
巻・号・頁	50(8),pp.571-7
著者・共著者	Takeuchi Hiroyuki, Kitade Mari, Kikuchi Iwaho, Shimanuki Hiroto, Kumakiri Jun, Kinoshita Katsuyuki
発行年月	2005/08
概要	OBJECTIVE:To examine the adhesion prevention effects of 2 types of fibrin sealant after laparoscopic myomectomy (LM).STUDY DESIGN:A prospective, randomized study (Canadian Task Force I) was conducted at a University-affiliated hospital. A total of 91 patients showing a minimal myoma > 5 cm, excluding pedunculated myomas, underwent LM alone: 32 patients in the control group, 29 in the fibrin gel group and 30 patients in the fibrin sheet group. After LM, postoperative adhesions were evaluated by second-look laparoscopy. The frequency of postoperative adhesions was the main outcome.RESULTS:The frequency of postoperative adhesions of the uterus was significantly lower (p < 0.05) in the fibrin gel group, with 20/32 (62.5%) in the control group, 10/29 (34.5%) in the fibrin gel group and 20/30 (67.7%) in the fibrin sheet group. Although no significant differences were found in the incidence of de novo adnexal adhesions, the lowest rate was found in the fibrin gel group, with 4/32 patients (12.5%) in the control group, 2/29 patients (6.8%) in the fibrin gel group and 5/30 patients (16.7%) in the fibrin sheet group. No bilateral adnexal adhesions were observed in the 3 groups.CONCLUSION:After LM for myomas as large as > or = 5 cm, postoperative adhesions were observed in > or = 50% of patients. The use of fibrin gel after LM is recommended.
PMID	16220761