ナカオ　リサコ   Nakao Risako   中尾　梨沙子    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Papillary muscle ischemia on high-resolution cine imaging of nitrogen-13 ammonia positron emission tomography: Association with myocardial flow reserve and prognosis in coronary artery disease.
掲載誌名	正式名：Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 略　 称：J Nucl Cardiol ISSNコード：10713581/15326551
掲載区分	国外
出版社	Springer
巻・号・頁	pp.in press
著者・共著者	NAKAO Risako†, NAGAO Michinobu*, YAMAMOTO Atsushi,, FUKUSHIMA Kenji, WATANABE Eri, SAKAI Shuji, HAGIWARA Nobuhisa
担当区分	筆頭著者
発行年月	2020/06
概要	BACKGROUND:The evaluation of papillary muscle (PM) perfusion through existing perfusion imaging, including single-photon emission computed tomography and magnetic resonance imaging, is not possible. Therefore, this study sought to investigate the detection of PM ischemia in coronary artery disease (CAD) using nitrogen-13 (N-13) ammonia positron emission tomography (NH3 PET) and its association with global myocardial flow reserve (MFR) and major adverse cardiac events (MACE).METHODS:Data of adenosine-stress NH3 PET for 263 consecutive patients with known or suspected CAD were retrospectively analyzed. PM ischemia was defined as the absence of PM accumulation under stress conditions and PM presence at rest on high-resolution cine imaging derived from PET-computed tomography scanner with time-of-flight technology. The primary outcome was MACE.RESULTS:Of 263 patients, 30 experienced mean follow-up period of 910 days (MACE), while 31 (11.8%) presented PM ischemia. Compared to patients without PM ischemia, those with PM ischemia reported a significantly lower global MFR and a significantly higher rate of MACE (P < .0001).CONCLUSION:NH3 PET enables the detection of PM ischemia in approximately 10% of patients with known or suspected CAD. PM ischemia is associated with reduced global MFR and is an important sign in predicting prognosis.
DOI	10.1007/s12350-020-02231-z
PMID	32566962