オノ　マサフミ   Ono Masafumi   小野　正文    所属   医学部 医学科（附属足立医療センター）    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease.
掲載誌名	正式名：BMC gastroenterology 略　 称：BMC Gastroenterol ISSNコード：1471230X/1471230X
掲載区分	国外
巻・号・頁	12,pp.16
著者・共著者	Yoneda Masato, Naka Shuhei, Nakano Kazuhiko, Wada Koichiro, Endo Hiroki, Mawatari Hironori, Imajo Kento, Nomura Ryota, Hokamura Kazuya, Ono Masafumi, Murata Shogo, Tohnai Iwai, Sumida Yoshio, Shima Toshihide, Kuboniwa Masae, Umemura Kazuo, Kamisaki Yoshinori, Amano Atsuo, Okanoue Takeshi, Ooshima Takashi, Nakajima Atsushi
発行年月	2012/02
概要	BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome that is closely associated with multiple factors such as obesity, hyperlipidemia and type 2 diabetes mellitus. However, other risk factors for the development of NAFLD are unclear. With the association between periodontal disease and the development of systemic diseases receiving increasing attention recently, we conducted this study to investigate the relationship between NAFLD and infection with Porphyromonas gingivalis (P. gingivalis), a major causative agent of periodontitis.METHODS:The detection frequencies of periodontal bacteria in oral samples collected from 150 biopsy-proven NAFLD patients (102 with non-alcoholic steatohepatitis (NASH) and 48 with non-alcoholic fatty liver (NAFL) patients) and 60 non-NAFLD control subjects were determined. Detection of P. gingivalis and other periodontopathic bacteria were detected by PCR assay. In addition, effect of P. gingivalis-infection on mouse NAFLD model was investigated. To clarify the exact contribution of P. gingivalis-induced periodontitis, non-surgical periodontal treatments were also undertaken for 3 months in 10 NAFLD patients with periodontitis.RESULTS:The detection frequency of P. gingivalis in NAFLD patients was significantly higher than that in the non-NAFLD control subjects (46.7% vs. 21.7%, odds ratio: 3.16). In addition, the detection frequency of P. gingivalis in NASH patients was markedly higher than that in the non-NAFLD subjects (52.0%, odds ratio: 3.91). Most of the P. gingivalis fimbria detected in the NAFLD patients was of invasive genotypes, especially type II (50.0%). Infection of type II P. gingivalis on NAFLD model of mice accelerated the NAFLD progression. The non-surgical periodontal treatments on NAFLD patients carried out for 3 months ameliorated the liver function parameters, such as the serum levels of AST and ALT.CONCLUSIONS:Infection with high-virulence P. gingivalis might be an addi
DOI	10.1186/1471-230X-12-16
PMID	22340817