オノ　マサフミ   Ono Masafumi   小野　正文    所属   医学部 医学科（附属足立医療センター）    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD.
掲載誌名	正式名：Scientific reports 略　 称：Sci Rep ISSNコード：20452322/20452322
掲載区分	国外
巻・号・頁	8(1),pp.10434
著者・共著者	Kawaguchi Takumi, Tokushige Katsutoshi, Hyogo Hideyuki, Aikata Hiroshi, Nakajima Tomoaki, Ono Masafumi, Kawanaka Miwa, Sawada Koji, Imajo Kento, Honda Koichi, Takahashi Hirokazu, Mori Kohjiroh, Tanaka Saiyu, Seko Yuya, Nozaki Yuichi, Kamada Yoshihiro, Fujii Hideki, Kawaguchi Atsushi, Takehara Tetsuo, Yanase Mikio, Sumida Yoshio, Eguchi Yuichiro, Seike Masataka, Yoneda Masato, Suzuki Yasuaki, Saibara Toshiji, Karino Yoshiyasu, Chayama Kazuaki, Hashimoto Etsuko, George Jacob, Torimura Takuji
発行年月	2018/07
概要	The prognosis of patients with nonalcoholic fatty liver disease-related hepatocellular carcinoma (NAFLD-HCC) is intricately associated with various factors. We aimed to investigate the prognostic algorithm of NAFLD-HCC patients using a data-mining analysis. A total of 247 NAFLD-HCC patients diagnosed from 2000 to 2014 were registered from 17 medical institutions in Japan. Of these, 136 patients remained alive (Alive group) and 111 patients had died at the censor time point (Deceased group). The random forest analysis demonstrated that treatment for HCC and the serum albumin level were the first and second distinguishing factors between the Alive and Deceased groups. A decision-tree algorithm revealed that the best profile comprised treatment with hepatectomy or radiofrequency ablation and a serum albumin level ≥3.7 g/dL (Group 1). The second-best profile comprised treatment with hepatectomy or radiofrequency ablation and serum albumin levels <3.7 g/dL (Group 2). The 5-year overall survival rate was significantly higher in the Group 1 than in the Group 2. Thus, we demonstrated that curative treatment for HCC and serum albumin level >3.7 g/dL was the best prognostic profile for NAFLD-HCC patients. This novel prognostic algorithm for patients with NAFLD-HCC could be used for clinical management.
DOI	10.1038/s41598-018-28650-0
PMID	29992975