オノ　マサフミ   Ono Masafumi   小野　正文    所属   医学部 医学科（附属足立医療センター）    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prevalence of pruritus in patients with chronic liver disease: A multicenter study.
掲載誌名	正式名：Hepatology research : the official journal of the Japan Society of Hepatology 略　 称：Hepatol Res ISSNコード：13866346/13866346
掲載区分	国内
巻・号・頁	48(3),pp.E252-E262
著者・共著者	Oeda Satoshi, Takahashi Hirokazu, Yoshida Hisako, Ogawa Yuji, Imajo Kento, Yoneda Masato, Koshiyama Yuichi, Ono Masafumi, Hyogo Hideyuki, Kawaguchi Takumi, Fujii Hideki, Nishino Ken, Sumida Yoshio, Tanaka Saiyu, Kawanaka Miwa, Torimura Takuji, Saibara Toshiji, Kawaguchi Atsushi, Nakajima Atsushi, Eguchi Yuichiro,
発行年月	2018/02
概要	AIM:Pruritus is a common comorbidity in chronic liver disease. The aim of this study was to clarify the prevalence of pruritus and its characteristics in patients with chronic liver disease.METHODS:A total of 1631 patients with chronic liver disease who attended one of nine joint-research facilities from January to June 2016 were enrolled. We investigated the prevalence of pruritus, itch location, itch duration, daily itch fluctuation, seasonal itch exacerbation, treatment drugs, and therapeutic effects using a medical interview questionnaire.RESULTS:The median age was 66 years and 890 (54.6%) patients were women. The prevalence of pruritus was 40.3% (658/1631), and it differed according to the underlying liver disease. The most frequent body location for pruritus was on the back (63.1%). Pruritus duration was more than 6 months in 252 (38.3%) patients. The severity of pruritus, assessed using a visual analog scale, was higher during the day than at night (median, 4 vs. 3, P < 0.001). Seasonal exacerbation was observed in 296 (45.0%) patients. Although 301 (45.7%) patients were treated with antipruritic agents, 57.8% (174/301) patients reported an insufficient effect. Active hepatitis B virus infection (odds ratio [OR], 2.51; P = 0.043), primary biliary cholangitis (OR, 3.69; P = 0.018), diabetes (OR, 1.57; P = 0.010), and aspartate aminotransferase ≥60 U/L (OR, 2.06; P = 0.011) were independent factors associated with pruritus.CONCLUSION:The prevalence of pruritus varies according to the chronic liver disease etiology. Underlying liver disease, aspartate aminotransferase ≥60 U/L, and comorbid diabetes are factors associated with pruritus in patients with chronic liver disease.
DOI	10.1111/hepr.12978
PMID	28877392