ワカバヤシ　ヒデタカ   Wakabayashi Hidetaka   若林　秀隆    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Influence of potentially inappropriate medications on activities of daily living for patients with osteoporotic vertebral compression fractures: A retrospective cohort study.
掲載誌名	正式名：Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 略　 称：J Orthop Sci ISSNコード：14362023/09492658
掲載区分	国外
巻・号・頁	pp.1-5
著者・共著者	Nagai Takako, Wakabayashi Hidetaka, Maeda Keisuke, Momosaki Ryo, Nishiyama Ai, Murata Hiroyasu, Uei Hiroshi
担当区分	2nd著者
発行年月	2020/04
概要	PURPOSE:Potentially inappropriate medications (PIMs) are a major concern in geriatric care. Osteoporotic vertebral compression fractures (OVCFs) are more common among the elderly, who are more likely to receive long-term analgesics for pain and additional medications for complications, but no studies have examined the effects of PIMs on OVCFs. The purpose of our study was to clarify the association between PIMs and activities of daily living (ADL) among patients with OVCFs.METHODS:The subjects were 170 patients aged 65 years or older with OVCFs treated conservatively who underwent rehabilitation between October 2014 and August 2019. Patients' clinical information, including age, sex, body mass index, total number of drugs used for treatment at admission, number and type of PIMs used at admission, bone mineral density, use of drugs for osteoporosis, fracture type, comorbidity severity, nutritional status, Barthel Index (BI), presence and extent of lower back pain, and length of hospital stay were examined retrospectively. The possible association between these clinical factors and the BI and use of PIMs was assessed.RESULTS:Ninety-seven patients (57.1%) were prescribed PIMs at admission. Mean BI at discharge was significantly lower among patients receiving PIMS (70 points vs. 83 points; p < 0.001). Multivariate analysis for BI gain after propensity score matching showed that the number of PIMs and BI at admission affected the BI gain.CONCLUSION:The use of PIMs hindered the improvement in ADL. Our results demonstrate the importance of appropriate drug control for patients with OVCFs.
DOI	10.1016/j.jos.2020.03.015
PMID	32307184