ムラガキ　ヨシヒロ   Muragaki Yoshihiro   村垣　善浩    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	A novel reaction force-fluorescence measurement system for evaluating pancreatic juice leakage from an excised swine pancreas during distal pancreatectomy
掲載誌名	正式名：Journal of hepato-biliary-pancreatic sciences. 略　 称：J Hepatobiliary Pancreat Sci ISSNコード：18686974/18686982
掲載区分	国内
出版社	Japanese Society of Hepato-Biliary-Pancreatic Surgery
巻・号・頁	27(11),pp.877-886
著者・共著者	KOBAYASHI Etsuko†, TSUCHIYA Shuto, AKAGI Yuko, TOMII Naoki, NAKAGAWA Keiichi, INAI Kunihiro, MURAGAKI Yoshihiro, ASANO Takehide, KIM Daeyoung
発行年月	2020/06/08
概要	Background/purpose: Resection using a stapler is a popular approach to distal pancreatectomy. However, the resulting leakage of pancreatic juice represents a serious problem. We have developed a force-fluorescence measurement as a first step towards the quantitative evaluation of pancreatic leakage due to tissue tearing under compression. Methods: The system comprises a testing machine with an indenter, similar in size to a stapler, which controls compression speed and measures reaction force, and a fluorescence measurement system to measure pancreatic juice leakage. Pancreatic juice leakage is measured as the maximum value of the increasing rate of fluorescence intensity (max value). Ten excised swine pancreases were compressed at a speed of 500, 100, and 10 mm/min until their thicknesses became 2 mm. Results: A strong positive correlation (0.804) was observed between the increase in max value before and after compression and the amount of reaction force drop due to tissue destruction. No pancreatic juice leakage was observed when compressed slowly (10 mm/min). Conclusions: We have successfully developed a novel force-fluorescence measurement system that can detect and quantify pancreatic juice leakage caused by tissue tearing. This system can determine the optimal compression conditions for preventing pancreatic juice leakage.
DOI	10.1002/jhbp.775
PMID	32510850