ヤギシタ　ダイゴ   Yagishita Daigo   柳下　大悟    所属   医学部 医学科（東京女子医科大学病院）    職種   寄附部門准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Comparison of high-power and conventional-power radiofrequency energy deliveries in pulmonary vein isolation using unipolar signal modification as a local endpoint.
掲載誌名	正式名：Journal of cardiovascular electrophysiology 略　 称：J Cardiovasc Electrophysiol ISSNコード：10453873/15408167
掲載区分	国外
出版社	Wiley Periodicals, Inc.
巻・号・頁	pp.in press
著者・共著者	EJIMA Koichiro†*, HIGUCHI Satoshi, YAZAKI Kyoichiro, KATAOKA Shohei, YAGISHITA Daigo, KANAI Miwa, SHODA Morio, HAGIWARA Nobuhisa
発行年月	2020/05
概要	INTRODUCTION:Negative component abolition of the unipolar signal (unipolar signal modification [USM]) reflects the lesion transmurality. The purpose of this study was to compare the procedural safety and outcome between high-power and conventional power atrial radiofrequency applications during a pulmonary vein isolation (PVI) using USM as a local endpoint. METHODS AND RESULTS:High-power (50W) and conventional power (25-40W) applications were compared among 120 consecutive patients with paroxysmal atrial fibrillation who underwent a USM-guided PVI. The first 60 patients were treated with conventional power (CP group) and last 60 with high-power (HP group). The atrial radiofrequency applications lasted for 5-10 s (CP group) or 3-5 s (HP group) after the USM. All procedures were performed using 3D mapping systems with image integration and esophageal temperature monitoring. The baseline characteristics were similar between the two groups. The HP group had fewer acute PV reconnections (62% vs. 78%, p=0.046) and a reduced procedure time (119.3±28.1 vs. 140.1±51.2 min, p=0.04). Freedom from recurrence after a single ablation procedure without any anti-arrhythmic drugs was higher in the HP group than CP group (88.3% vs. 73.3% at 12-months after the procedure, log-rank, p=0.0423). There were no major complications that required any intervention. CONCLUSIONS:The high-power PVI guided by USM decreased the procedural time and may improve the procedural outcomes without compromising the safety. This article is protected by copyright. All rights reserved.
DOI	10.1111/jce.14532
PMID	32378266