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ササキ ダイスケ
Sasaki Daisuke
佐々木 大輔 所属 医学研究科 医学研究科 (医学部医学科をご参照ください) 職種 特任助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Myocardial sarcomeres spontaneously oscillate with the period of heartbeat under physiological conditions. |
| 掲載誌名 | 正式名：Biochemical and biophysical research communications 略 称：Biochem Biophys Res Commun ISSNコード：0006291X/0006291X |
| 掲載区分 | 国外 |
| 巻・号・頁 | 343(4),pp.1146-52 |
| 著者・共著者 | Sasaki Daisuke, Fukuda Norio, Ishiwata Shin'ichi |
| 発行年月 | 2006/05 |
| 概要 | During heartbeat, the repeated contractions of myocardium are induced by the oscillation of intracellular Ca(2+) concentration. On the other hand, when intermediately activated at a certain Ca(2+) concentration, cardiac myofibrils exhibit the spontaneous sarcomeric oscillation (Ca-SPOC) under steady ionic conditions. In the present study, we found that Ca-SPOC occurred over a wide range of Ca(2+) concentrations, including physiological contractile conditions, in skinned myocardium prepared from various animal species (rat, rabbit, pig, and cow). The period of sarcomeric oscillation fell within the same range as the period of heartbeat of each animal species. On the basis of these results we propose that the intrinsic auto-oscillatory property of sarcomeres (myofibrils) significantly contributes to myocardial beating in vivo. |
| DOI | 10.1016/j.bbrc.2006.03.070 |
| PMID | 16579966 |