シノハラ　アキヒト   Shinohara Akihito   篠原　明仁    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Hematopoietic Stem Cell Transplantation in Solid Organ Recipients with Emphasis on Transplant Complications: A Nationwide Retrospective Survey on Behalf of the Japan Society for Hematopoietic Stem Cell Transplantation Transplant Complications Working Group.
掲載誌名	正式名：Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 略　 称：Biol Blood Marrow Transplant ISSNコード：15236536/10838791
掲載区分	国外
巻・号・頁	26(1),pp.66-75
著者・共著者	Shinohara Akihito†*, Oshima Kumi, Fuji Shigeo, Umeda Katsutsugu, Kako Shinichi, Kurokawa Mineo, Tsukada Nobuhiro, Kasai Masanobu, Kondo Takakazu, Hashii Yoshiko, Nakamae Hirohisa, Ikegame Kazuhiro, Kosaka Yoshiyuki, Shimada Akira, Nawa Yuichiro, Makoto Yoshimitsu, Yoshiko Atsuta, Fukuda Takahiro, Tanaka Junji, Ogata Masao
担当区分	筆頭著者,責任著者
発行年月	2019/09
概要	Little is known about stem cell transplantation in solid organ transplantation (SOT) recipients. We conducted a nationwide retrospective survey of Japan Society for Hematopoietic Stem Cell Transplantation centers. A total of 19 patients who underwent 22 hematopoietic stem cell transplantations (HSCTs) after SOT were identified: 5 autologous HSCTs and 17 allogeneic HSCTs were performed. Patients who underwent autologous HSCT received a liver (n = 4) or kidney (n = 1) transplant. All 5 patients achieved neutrophil engraftment, and 2 of 3 patients with hepatoblastoma were alive at 1 year after HSCT. Allogeneic HSCT was performed in 16 patients (7 liver transplant recipients and 9 kidney transplant recipients). Among these, 2 donors were identical for both transplantations. All but 1 patient achieved neutrophil engraftment. The 5-year overall survival rate was 41.7%, but that in patients with malignant disease (n = 13) was much lower than the overall rate (23.1%). Only 1 patient with malignant disease underwent allogeneic HSCT in nonremission. In allogeneic HSCT after kidney transplantation, post-transplantation (1 year) kidney function in 5 evaluable patients was significantly lower than that before allogeneic HSCT, and 3 patients experienced renal rejection. However, no severe hepatic rejection was noted. In SOT recipients, HSCT is a potentially curable treatment for hematologic disorders, but it must be performed with caution, especially in patients with malignancy.
DOI	10.1016/j.bbmt.2019.08.021
PMID	31494230