ニシノ　タカヨシ   Nishino Takayoshi   西野　隆義    所属   医学部 医学科（附属八千代医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients.
掲載誌名	正式名：Pancreas 略　 称：Pancreas ISSNコード：15364828/08853177
巻・号・頁	48(1),pp.49-54
著者・共著者	Ito Tetsuya, Kawa Shigeyuki, Matsumoto Akihiro, Kubota Kensuke, Kamisawa Terumi, Okazaki Kazuichi, Hirano Kenji, Hirooka Yoshiki, Uchida Kazushige, Masuda Atsuhiro, Ohara Hirotaka, Shimizu Kyoko, Arakura Norikazu, Masamune Atsushi, Kanno Atsushi, Sakagami Junichi, Itoi Takao, Ito Tetsuhide, Ueki Toshiharu, Nishino Takayoshi, Inui Kazuo, Mizuno Nobumasa, Yoshida Hitoshi, Sugiyama Masanori, Iwasaki Eisuke, Irisawa Atsushi, Shimosegawa Tooru, Chiba Tsutomu
発行年月	2019/01
概要	OBJECTIVE:Autoimmune pancreatitis (AIP) has the potential to transform into chronic pancreatitis with pancreatic stone involvement. This retrospective investigation sought to clarify the risk factors for stone formation in type 1 AIP.METHODS:Questionnaires on patients with type 1 AIP were sent to 22 high-volume medical centers across Japan to compare the clinical features of patients with and without pancreatic stone formation.RESULTS:Of the completed records on 624 type 1 AIP patients, 31 (5%) had experienced pancreatic stones. Median follow-up duration was 1853 days. Bentiromide test values at diagnosis were significantly lower, and hemoglobin A1c values after corticosteroid treatment were significantly higher in patients with pancreatic stones. Imaging results disclosed that pancreatic atrophy and hilar or intrahepatic bile duct stenosis were significantly more frequent in patients with pancreatic stone formation. Pancreatic head swelling tended to be more frequent in this group as well. On the other hand, a shorter follow-up period was associated with the nonformation of pancreatic stones.CONCLUSIONS:The increased frequency of pancreatic head swelling in type 1 AIP patients exhibiting pancreatic stones indicated a propensity for pancreatic juice stasis with subsequent stone development and pancreatic dysfunction occurring over longer periods of disease duration.
DOI	10.1097/MPA.0000000000001210
PMID	30540679