コテラ　ヨシヒト   Kotera Yoshihito   小寺　由人    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Current status of hepatopulmonary syndrome in liver transplantation in Japan: a Japanese multicenter analysis.
掲載誌名	正式名：Journal of hepato-biliary-pancreatic sciences 略　 称：J Hepatobiliary Pancreat Sci ISSNコード：18686982/18686974
巻・号・頁	26(7),pp.292-299
著者・共著者	Kotera Yoshihito, Egawa Hiroto, Ogata Satoshi, Teramukai Satoshi, Kaido Toshimi, Shirabe Ken, Taketomi Akinobu, Takada Yasutugu, Yamamoto Masakazu, Yamaue Hiroki,
担当区分	筆頭著者
発行年月	2019/07
概要	BACKGROUND:Hepatopulmonary syndrome (HPS) negatively affects the outcomes of deceased donor liver transplantation (LT).METHODS:We retrospectively reviewed the clinical records of patients with HPS who underwent LT and studied the impact of risk factors on clinical outcomes to determine strategies to overcome complications. Patients with symptoms of hypo-oxygenemia and a shunt ratio >15% on 99mTc-MAA lung perfusion scintigraphy were defined as having HPS.RESULTS:Forty-eight patients in 10 centers were enrolled. Diseases included biliary atresia, liver cirrhosis, non-alcoholic steatohepatitis, congenital hepatic fibrosis, and others. The length of ICU stay was 2-170 days. The respirator was used for 41.6% of patients on post-operative day (POD) 3 and 20.8% on POD 14. The patient survival rate was 87% at 1 year and 82% at 5 years. The causes of hospital mortality were sepsis, thrombotic microangiopathy, intracranial bleeding, pulmonary fibrosis, and transplant rejection. An amount of shunt ratio prior to LT was a significant risk factor for hospital mortality. Hypoxia from POD 3 to POD 14 was a risk factor for biliary stenosis. The shunt ratio of all surviving patients significantly improved.CONCLUSION:Although LT is feasible for patients with HPS, early transplantation and avoiding hypo-oxygenemia immediately after transplantation are important.
DOI	10.1002/jhbp.632
PMID	31069999