イズモ　ワタル   Izumo Wataru   出雲　渉    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Impact of Antibodies That React With Liver Tissue and Donor-Specific Anti-HLA Antibodies in Pediatric Idiopathic Posttransplantation Hepatitis.
掲載誌名	正式名：Transplantation 略　 称：Transplantation ISSNコード：15346080/00411337
巻・号・頁	101(5),pp.1074-1083
著者・共著者	Hirata Yoshihiro, Yoshizawa Atsushi, Egawa Hiroto, Ueda Daisuke, Okamoto Shinya, Okajima Hideaki, Yurugi Kimiko, Hishida Rie, Hirai Hideyo, Miyagawa-Hayashino Aya, Maekawa Taira, Haga Hironori, Uemoto Sinji
発行年月	2017/05
概要	BACKGROUND:The cause of late graft dysfunction has not been elucidated. Although an antibody-mediated reaction is suspected as a potential mechanism, the target antigens have not been clarified.METHODS:To clarify the etiology of idiopathic posttransplantation hepatitis (IPTH), we simultaneously examined the presence of antibodies that react with liver tissue (ARLT) by means of indirect immunofluorescence staining, as well as the presence of donor-specific anti-human leukocyte antigen antibodies (HLA-DSA). A subanalysis of the IPTH group was also performed. Within the IPTH group, the correlation between ARLT titer and clinical data were analyzed.RESULTS:In the sera of patients with IPTH (30 patients), ARLT were found at a significantly higher frequency than in patients without IPTH (42 patients; P < 0.001). Moreover, the ARLT titer appeared to be correlated with the severity of hepatitis or hepatic injury. In contrast, the frequency of HLA-DSA was significantly lower in patients with IPTH than in patients without IPTH (P = 0.001).CONCLUSION:Our findings indicate that ARLT, and not HLA-DSA, profoundly influence the etiology of IPTH.
DOI	10.1097/TP.0000000000001653
PMID	28118175