ナカムラ　シンイチ   Nakamura Shin'ichi   中村　真一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease.
掲載誌名	正式名：Digestion 略　 称：Digestion ISSNコード：14219867/00122823
掲載区分	国外
巻・号・頁	95(1),pp.61-66
著者・共著者	Øverby Anders, Murayama Somay Y, Michimae Hirofumi, Suzuki Hidekazu, Suzuki Masayuki, Serizawa Hiroshi, Tamura Ryo, Nakamura Shinichi, Takahashi Shinichi, Nakamura Masahiko
発行年月	2017
概要	BACKGROUND:Non-Helicobacter pylori-helicobacters (NHPH) compose a group of gram negative zoonotic bacteria that may induce in humans gastric diseases including gastritis, gastroduodenal ulcer and MALT lymphoma. Their prevalence in the general population has previously been reported to 0.1-6.2%, although such reports still remain less in number.AIMS:This study aimed at estimating the prevalence of gastric NHPH in Japanese people, and further aimed at linking this to different gastric diseases and co-infection with H. pylori.METHODS:Endoscopically obtained biopsy samples from 280 Japanese patients with various gastric diseases were collected. Samples were analyzed by immunohistochemistry and by species-specific PCR for detection of gastric helicobacters.RESULTS:The total prevalence of gastric NHPH among 280 Japanese patients was 6.1%, and the prevalence of H. pylori was 65.7%. There was no significant difference in prevalence of either NHPH or H. pylori when infected with H. pylori or NHPH, respectively. NHPH infection was found to be the highest in patients with gastric MALT lymphoma and duodenal ulcer, the former being independent of co-infection with H. pylori and the latter being dependent.CONCLUSIONS:This study reports a total prevalence of 6.1% of gastric NHPH in Japanese patients, and further highlights gastric MALT lymphoma and duodenal ulcer (when co-infected with H. pylori) as important related diseases.
DOI	10.1159/000452400
PMID	28052279