オカザキ　ケン   Okazaki Ken   岡崎　賢    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Degenerative changes in cartilage likely occur in the medial compartment after anterior cruciate ligament reconstruction.
掲載誌名	正式名：Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 略　 称：Knee Surg Sports Traumatol Arthrosc ISSNコード：14337347/09422056
掲載区分	国外
巻・号・頁	27(11),pp.3567-3574
著者・共著者	Ushio Tetsuro†, Okazaki Ken*, Osaki Kanji, Takayama Yukihisa, Sagiyama Koji, Mizu-Uchi Hideki, Hamai Satoshi, Akasaki Yukio, Honda Hiroshi, Nakashima Yasuharu
担当区分	2nd著者,責任著者
発行年月	2019/11
概要	PURPOSE:Magnetic resonance imaging with T1ρ mapping is used to quantify the amount of glycosaminoglycan in articular cartilage, which reflects early degenerative changes. The purposes of this study were to evaluate early degenerative changes in knees after anterior cruciate ligament (ACL) reconstruction by comparing T1ρ values before and 2 years after surgery and investigate whether surgical factors and clinical outcomes are related to differences in T1ρ values.METHODS:Fifty patients who underwent unilateral primary ACL reconstruction were evaluated using T1ρ mapping before and 2 years after surgery. Three regions of interest (ROIs) were defined in the cartilage associated with the medial (M) and lateral (L) weight-bearing areas of the femoral condyle (FC) (anterior: MFC1 and LFC1, middle: MFC2 and LFC2, and posterior: MFC3 and LFC3). Two ROIs associated with the tibial plateau (T) were defined (anterior: MT1 and LT1, and posterior: MT2 and LT2). T1ρ values within the ROIs were measured before and 2 years after surgery and compared using the paired t test. Correlations between the difference in T1ρ values at these two time points and patient characteristics, presence of a cartilaginous lesion, graft type, and postoperative anteroposterior laxity were also evaluated using Pearson's and Spearman's correlation coefficients.RESULTS:There was a significant increase in T1ρ before versus 2 years after surgery in the MT1, MT2, LFC1, and LT1 areas, and a significant decrease in the LFC3 and LT2 areas.
DOI	10.1007/s00167-019-05468-5
PMID	30879110