イシズ　アヤコ   ISHIZU Ayako   石津　綾子    所属   医学部 医学科    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Sphere formation restores and confers hair-inducing capacity in cultured mesenchymal cells.
掲載誌名	正式名：Experimental dermatology 略　 称：Exp Dermatol ISSNコード：16000625/09066705
掲載区分	国外
巻・号・頁	20(8),pp.679-81
著者・共著者	Shimizu Ruka, Okabe Keisuke, Kubota Yoshiaki, Nakamura-Ishizu Ayako, Nakajima Hideo, Kishi Kazuo
発行年月	2011/08
概要	Interactions between epithelial and dermal cells are essential for hair follicle morphogenesis and maintenance. In experimental trials of hair regeneration, isolated dermal cells have been shown to possess hair-inducing capacity. However, dermal cells lose this potential immediately after cultivation. Sphere-forming multipotent cells derived from the dermis possess hair-inducing capacity. These previous findings raise the question of whether hair-inducing capacity depends on the identity as dermal cells or the process of sphere formation. To address this issue, we compared the in vitro and in vivo characteristics of two-dimensionally cultured or thereafter sphere formation-induced dermal and lung mesenchymal cells. We show that sphere-forming mesenchymal cells exhibited higher expression of Wnt signalling genes. Sphere-forming cells but not two-dimensionally cultured cells possessed in vivo hair-inducing capacity. These data suggest that various mesenchymal cells attain hair-inducing capacity through the process of sphere formation.
DOI	10.1111/j.1600-0625.2011.01281.x
PMID	21521371