イシズ　アヤコ   Ishizu Ayako   石津　綾子    所属   医学部 医学科    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero.
掲載誌名	正式名：The Journal of experimental medicine 略　 称：J Exp Med ISSNコード：15409538/00221007
掲載区分	国外
巻・号・頁	208(5),pp.949-60
著者・共著者	Kubota Yoshiaki, Takubo Keiyo, Hirashima Masanori, Nagoshi Narihito, Kishi Kazuo, Okuno Yuji, Nakamura-Ishizu Ayako, Sano Keigo, Murakami Masato, Ema Masatsugu, Omatsu Yoshiki, Takahashi Satoru, Nagasawa Takashi, Shibuya Masabumi, Okano Hideyuki, Suda Toshio
発行年月	2011/05
概要	Vasculogenesis describes the process of de novo vessel formation from vascular precursor cells. Although formation of the first major vessels, such as the dorsal aorta and cardinal veins, occurs during embryonic vasculogenesis, the contribution of precursor cell populations to postnatal vessel development is not well understood. Here, we identified a novel population of postnatal vascular precursor cells in mice. These cells express the Schwann cell protein myelin protein zero (Po) and exhibit a CD45(-)CD31(-)VEcad(-)c-kit(+)CXCR4(+) surface phenotype. Po(+) vascular precursors (PVPs) are recruited into the growing vasculature, and comprise a minor population of arterial endothelial cells in adult mice. Recruitment of PVPs into growing vessels is mediated by CXCL12-CXCR4 signaling, and is enhanced during vascular expansion induced by Notch inhibition. Po-specific ablation of Flk1, a receptor for VEGF, results in branching defects and insufficient arterial patterning in the retina, as well as reduced neovascularization of tumors and ischemic tissues. Thus, in postnatal mice, although growing vessels are formed primarily by angiogenesis from preexisting vessels, a minor population of arterial endothelia may be derived from tissue-resident vascular precursor cells.
DOI	10.1084/jem.20102187
PMID	21536740