イシズ　アヤコ   Ishizu Ayako   石津　綾子    所属   医学部 医学科    職種   教授・基幹分野長
論文種別	原著
言語種別	日本語
査読の有無	査読あり
表題	Recruited peripheral blood monocytes participate in the liver extramedullary hematopoietic milieu.
掲載誌名	正式名：Archives of histology and cytology 略　 称：Arch Histol Cytol ISSNコード：13491717/09149465
掲載区分	国外
巻・号・頁	73(3),127-37頁
著者・共著者	Nakamura-Ishizu Ayako, Morikawa Shunichi, Shimizu Kazuhiko, Ezaki Taichi
発行年月	2010
概要	The hematopoietic microenvironment has been investigated and well defined in the bone marrow. However, there is a lack of studies on the extramedullary hematopoietic milieu such as in the liver, to which hematopoietic stem cells migrate and there commence hematopoiesis under pathological conditions such as bone marrow failure. We induced extramedullary hematopoiesis by phenylhydrazine in the adult mouse liver and investigated the immunohistochemical, ultrastructural, and molecular changes within this organ. Using an intravital lectin injection technique, we found numerous monocytes attached to the central vein prior to hematopoietic foci formation. These cells were later incorporated into the hematopoietic foci. An increase in the mRNA expressions of the monocyte attracting chemokine CCL-2 (MCP-1) was noted in the central vein region as well as in cells within the hematopoietic foci. Together with local liver components, we regard these monocytes as components of the extramedullary hematopoietic milieu. We conclude that the recruitment of extra-hepatic monocytes is an important event during extramedullary hematopoiesis in the liver and that these monocytes participate in the liver hematopoietic microenvironment.
DOI	10.1679/aohc.73.127
PMID	22572180