イイダ　トモヒロ   Iida Tomohiro   飯田　知弘    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Clinical findings of acquired vitelliform lesions associated with retinal pigment epithelial detachments.
掲載誌名	正式名：American journal of ophthalmology 略　 称：Am J Ophthalmol ISSNコード：18791891/00029394
掲載区分	国外
巻・号・頁	157(2),pp.355-365.e2
著者・共著者	Saito Masaaki, Iida Tomohiro, Freund K Bailey, Kano Mariko, Yannuzzi Lawrence A
担当区分	2nd著者
発行年月	2014/02
概要	PURPOSE:To study clinical findings associated with acquired vitelliform lesions in retinal pigment epithelial detachments (PEDs).DESIGN:Retrospective, interventional, consecutive case series.METHODS:We retrospectively reviewed 32 eyes of 24 patients (22 men, 2 women; age range [mean], 58-85 [73.7] years) with acquired vitelliform lesions.RESULTS:All eyes had acquired vitelliform lesions in the central macula associated with a serous PED at baseline. Of the 32 eyes, 30 (93.8%) were observed for 12 months, 26 (81.3%) for 24 months, and 17 (53.1%) for 36 months. The mean logarithm of the minimal angle of resolution best-corrected visual acuity (BCVA) levels were 0.19 at month 12, 0.28 at month 24, and 0.25 at month 36, none of which differed significantly from baseline. The mean changes in the BCVA were declines of 0.38, 1.29, and 1.21 lines at months 12, 24, and 36, respectively. Of 7 eyes treated with 3 consecutive monthly intravitreal injections of ranibizumab, the serous PEDs remained in all 7 eyes and the mean changes of BCVA were a decline of 2.40 lines 12 months after the first injection and a decline of 3.58 lines at the final visit. In the 24 untreated eyes, the mean change in the BCVA was a decline of 0.25 line at the final visit, which differed significantly (P = .021) compared with that of the treated eyes at the final visit.CONCLUSION:Intravitreal injections of ranibizumab were ineffective because of the absence of resolution of the PEDs and the declines in VA.
DOI	10.1016/j.ajo.2013.10.009
PMID	24439441