マルコ　イチロウ   Maruko Ichirou   丸子　一朗    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Correlation between reduction in macular vessel density and frequency of intravitreal ranibizumab for macular oedema in eyes with branch retinal vein occlusion.
掲載誌名	正式名：The British journal of ophthalmology 略　 称：Br J Ophthalmol ISSNコード：14682079/00071161
掲載区分	国外
巻・号・頁	103(1),pp.72-77
著者・共著者	Hasegawa Taiji, Murakawa Sakura, Maruko Ichiro, Kogure-Katakura Akiko, Iida Tomohiro
発行年月	2019/01
概要	AIM:To determine whether there is a significant correlation between the reduction in macular vessel density and the recurrence of macular oedema in eyes with branch retinal vein occlusion (BRVO).METHODS:We reviewed the medical records of 27 eyes with macular oedema associated with BRVO. All eyes had received pro re nata intravitreal ranibizumab (IVR) injection. A reinjection of ranibizumab was performed when the central foveal thickness was ≥300 µm. At 12 months, patients without additional IVR for the last 4 months were placed in the resolved group, otherwise they were placed in the recurrence group. The macular vessel density in 3×3 mm area centred on the fovea was determined by optical coherence tomography angiography.RESULTS:At 12 months, 11 of the 27 (40.7%) eyes were placed in the resolved group and the other 16 (59.3%) eyes were placed in the recurrence group. The mean macular vessel density reduction in the resolved group was 17.60%±7.88% and that in the recurrence group was 8.12%±7.48% (P=0.0042). The mean number of IVR injections in the resolved group was 2.1±1.1 and that in the recurrence group was 5.1±1.2 (P<0.0001). In all eyes, multivariate analysis showed that the reduction in macular vessel density was significantly and negatively correlated with the number of IVR injections (β=-0.6746, P=0.0028).CONCLUSIONS:A reduction in the macular vessel density was significantly correlated with the number of recurrences of macular oedema associated with BRVO.
DOI	10.1136/bjophthalmol-2017-311499
PMID	29545416