ナカムラ　フミオ   NAKAMURA Fumio   中村　史雄    所属   医学部 医学科    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Immunoreactivity of a G protein-coupled l-DOPA receptor GPR143, in Lewy bodies.
掲載誌名	正式名：Neuroscience research 略　 称：Neurosci Res ISSNコード：18728111/01680102
掲載区分	国外
巻・号・頁	148,pp.49-53
著者・共著者	Goshima Yoshio, Watanabe Shuya, Seki Erika, Koga Motokazu, Masukawa Daiki, Nakamura Fumio, Komori Takashi, Arai Nobutaka
発行年月	2019/11
概要	l-3,4-Dihydroxyphenylalanine (l-DOPA) has been believed to be an inert amino acid precursor of dopamine, and is the most effective therapeutic agent in Parkinson's disease (PD). We proposed l-DOPA as a neurotransmitter in the central nervous system. Recently, the ocular albinism 1 gene product, OA1/GPR143 (GPR143), was identified as a receptor for l-DOPA. In this study, we examined by generating anti-human GPR143 antibody, the localization of GPR143-immunoreactive signals in the brains from control and PD subjects. GPR143-immunoreactive signals were detected throughout the entire midbrain including substantia nigra pars compacta. In the PD brains, we found that GPR143-immunoreactive signals were detected in Lewy bodies and were colocalized with immunoreactive signals with anti-human Ser129 phosphorylated α-synuclein antibody. Although the significance of its occurrence in the inclusion bodies is unknown, our finding suggests possible implications of GPR143 in PD.
DOI	10.1016/j.neures.2018.12.004
PMID	30590075