ハギワラ　ノブヒサ   HAGIWARA Nobuhisa   萩原　誠久    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients.
掲載誌名	正式名：JAMA cardiology 略　 称：JAMA Cardiol ISSNコード：23806583/23806591
掲載区分	国外
出版社	American Medical Association
巻・号・頁	4(3),pp.246-254
著者・共著者	Shimizu Wataru*, Makimoto Hisaki, Yamagata Kenichiro, Kamakura Tsukasa, Wada Mitsuru, Miyamoto Koji, Inoue-Yamada Yuko, Okamura Hideo, Ishibashi Kohei, Noda Takashi, Nagase Satoshi, Miyazaki Aya, Sakaguchi Heima, Shiraishi Isao, Makiyama Takeru, Ohno Seiko, Itoh Hideki, Watanabe Hiroshi, Hayashi Kenshi, Yamagishi Masakazu, Morita Hiroshi, Yoshinaga Masao, Aizawa Yoshiyasu, Kusano Kengo, Miyamoto Yoshihiro, Kamakura Shiro, Yasuda Satoshi, Ogawa Hisao, Tanaka Toshihiro, Sumitomo Naotaka, Hagiwara Nobuhisa, Fukuda Keiichi, Ogawa Satoshi, Aizawa Yoshifusa, Makita Naomasa, Ohe Tohru, Horie Minoru, Aiba Takeshi
発行年月	2019/03
概要	CONCLUSIONS AND RELEVANCE: In this retrospective analysis, pathogenic variants in the pore areas of the channels were associated with higher risk of arrhythmic events than were other variants in each genotype, while sex-associated differences were observed in patients with LQT1 and LQT2 but not in those with LQT3. The findings of this study suggest that risk for cardiac events in LQTS varies according to genotype, variant site, age, and sex.
DOI	10.1001/jamacardio.2018.4925
PMID	30758498