|
ハギワラ ノブヒサ
HAGIWARA Nobuhisa
萩原 誠久 所属 医学部 医学科（東京女子医科大学病院） 職種 客員教授 |
|
| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients. |
| Journal | Formal name：JAMA cardiology Abbreviation：JAMA Cardiol ISSN code：23806583/23806591 |
| Domestic / Foregin | Foregin |
| Publisher | American Medical Association |
| Volume, Issue, Page | 4(3),pp.246-254 |
| Author and coauthor | Shimizu Wataru*, Makimoto Hisaki, Yamagata Kenichiro, Kamakura Tsukasa, Wada Mitsuru, Miyamoto Koji, Inoue-Yamada Yuko, Okamura Hideo, Ishibashi Kohei, Noda Takashi, Nagase Satoshi, Miyazaki Aya, Sakaguchi Heima, Shiraishi Isao, Makiyama Takeru, Ohno Seiko, Itoh Hideki, Watanabe Hiroshi, Hayashi Kenshi, Yamagishi Masakazu, Morita Hiroshi, Yoshinaga Masao, Aizawa Yoshiyasu, Kusano Kengo, Miyamoto Yoshihiro, Kamakura Shiro, Yasuda Satoshi, Ogawa Hisao, Tanaka Toshihiro, Sumitomo Naotaka, Hagiwara Nobuhisa, Fukuda Keiichi, Ogawa Satoshi, Aizawa Yoshifusa, Makita Naomasa, Ohe Tohru, Horie Minoru, Aiba Takeshi |
| Publication date | 2019/03 |
| Summary | CONCLUSIONS AND RELEVANCE: In this retrospective analysis, pathogenic variants in the pore areas of the channels were associated with higher risk of arrhythmic events than were other variants in each genotype, while sex-associated differences were observed in patients with LQT1 and LQT2 but not in those with LQT3. The findings of this study suggest that risk for cardiac events in LQTS varies according to genotype, variant site, age, and sex. |
| DOI | 10.1001/jamacardio.2018.4925 |
| PMID | 30758498 |