アズマ　ケンコウ   Azuma Kenkou   東　剣虹    所属   研究施設 研究施設    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Extension of chronological lifespan by ScEcl1 depends on mitochondria in Saccharomyces cerevisiae.
掲載誌名	正式名：Bioscience, biotechnology, and biochemistry 略　 称：Biosci Biotechnol Biochem ISSNコード：(1347-6947)0916-8451(Linking)
巻・号・頁	76(10),pp.1938-42
著者・共著者	Azuma Kenko, Ohtsuka Hokuto, Murakami Hiroshi, Aiba Hirofumi
担当区分	筆頭著者
発行年月	2012
概要	Ecl1, a product of the YGR146C gene in Saccharomyces cerevisiae, was identified as a factor involved in chronological lifespan. In this study we found evidence that the function of Ecl1 in the extension of chronological lifespan is dependent on mitochondrial function. The respiratory activity of cells increased when Ecl1 was overexpressed or cells were grown under calorie restriction, but there was no additive effect of calorie restriction and Ecl1 overexpression on increases in respiratory activity or on the extension of chronological lifespan. Based on these results, we propose that overexpression of Ecl1 has same effect as caloric restriction and that its function also depends on mitochondria, just like caloric restriction.
DOI	10.1271/bbb.120427
PMID	23047113