アズマ　ケンコウ   Azuma Kenkou   東　剣虹    所属   研究施設 研究施設    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	hsf1 (+) extends chronological lifespan through Ecl1 family genes in fission yeast.
掲載誌名	正式名：Molecular genetics and genomics : MGG 略　 称：Mol Genet Genomics ISSNコード：(1617-4623)1617-4623(Linking)
掲載区分	国外
巻・号・頁	285(1),pp.67-77
著者・共著者	Ohtsuka Hokuto, Azuma Kenko, Murakami Hiroshi, Aiba Hirofumi
担当区分	2nd著者
発行年月	2011/01
概要	The heat shock factor (HSF), a protein evolutionarily conserved from yeasts to human, regulates the expression of a set of proteins called heat shock proteins (HSPs), many of which function as molecular chaperones. In Saccharomyces cerevisiae, the HSF binds to the 5' upstream region of YGR146C and activates its transcription. YGR146C encodes a functional homolog of ecl1 (+), ecl2 (+), and ecl3 (+) of Schizosaccharomyces pombe. At present, these Ecl1 family genes, which are extenders of chronological lifespan, have been identified only in fungi groups. Based on ChIP analysis, we identified that Hsf1 binds to the upstream DNA region of ecl2 (+) after heat shock in S. pombe. In Caenorhabditis elegans, heat shock factor HSF-1 is known to regulate aging and required for the elongation of longevity by dietary restriction. We found that heat shock factor Hsf1 extends chronological lifespan of S. pombe when overexpressed. Moreover, we show that the extension of chronological lifespan by the overproduction of Hsf1 mainly depends on ecl2 (+) among Ecl1 family genes. From these results, we suggest that HSF is a conserved regulator of lifespan, at least in yeast and nematode, and Ecl1 family genes such as YGR146C and ecl2 (+) are the direct targets of Hsf1 and mediate lifespan extension by Hsf1.
DOI	10.1007/s00438-010-0588-6
PMID	21072667