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ヒグチ トモアキ
Higuchi Tomoaki
樋口 智昭 所属 医学部 医学科（東京女子医科大学病院） 職種 寄附部門講師 |
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| 論文種別 | 症例報告 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | A case of multicentric Castleman's disease having lung lesion successfully treated with humanized anti-interleukin-6 receptor antibody, tocilizumab. |
| 掲載誌名 | 正式名：Journal of Korean medical science 略 称：J Korean Med Sci ISSNコード：(1598-6357)1011-8934(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 25(9),pp.1364-7 |
| 著者・共著者 | Higuchi Tomoaki, Nakanishi Takashi, Takada Kunio, Matsumoto Mitsuyo, Okada Makoto, Horikoshi Hideyuki, Suzuki Kimihiro |
| 発行年月 | 2010/09 |
| 概要 | This report presents the case of a patient demonstrating multicentric Castleman's disease (MCD) with a lung lesion that was successfully treated with an anti-interleukin-6 receptor antibody, tocilizumab in combination with corticosteroid and tacrolimus. A 43-yr-old female with abnormal shadows on a chest X-ray was referred to the hospital for further examination. She was diagnosed as having MCD based on the characteristic pathology of inguinal lymph node, lung lesions, laboratory data, and undifferentiated arthritis. Corticosteroid and rituximab therapy did not fully ameliorate the symptoms; thus, the therapeutic regimen was changed to include tocilizumab, oral corticosteroid and tacrolimus. This regimen resulted in clinical remission and the dose of tocilizumab and corticosteroid could be tapered. Tocilizumab in combination with corticosteroid and tacrolimus may therefore be a beneficial treatment regimen for lung lesions associated with MCD. |
| DOI | 10.3346/jkms.2010.25.9.1364 |
| PMID | 20808682 |