ヒグチ　トモアキ   Higuchi Tomoaki   樋口　智昭    所属   医学部 医学科（東京女子医科大学病院）    職種   寄附部門講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The relationships between titers of anti-Ro or anti-La as measured by ELISA and salivary production rate with age correction.
掲載誌名	正式名：Modern rheumatology 略　 称：Mod Rheumatol ISSNコード：(1439-7595)1439-7595(Linking)
巻・号・頁	18(6),pp.578-84
著者・共著者	Takada Kunio, Suzuki Kimihiro, Matsumoto Mitsuyo, Okada Makoto, Nakanishi Takashi, Horikoshi Hideyuki, Higuchi Tomoaki, Nakayama Akiyoshi, Ohsuzu Fumitaka
発行年月	2008
概要	The objective of this work was to clarify the clinical significance of titers of anti-Ro and anti-La, the relationships between titers of either anti-Ro or anti-La, and salivary production rate (SPR). These autoantibodies were titrated using enzyme-linked immunosorbent assay. The Saxon test was performed to measure SPR. Fifty-one females who had anti-Ro but not anticentromere antibodies or anti-U1RNP were enrolled. SPR decreased significantly with age. In order to exclude the effect of aging on SPR, we calculated the "SPR with age correction." According to the results of a multiple regression analysis, only the anti-La titer was significantly associated with SPR with age correction. The distribution pattern of the anti-La titers consisted of two subgroups (with a titer index cutoff of 100.0): a negative anti-La titer (anti-La<25.0) and low anti-La titer (25.0<or=anti-La<100.0) group, and a high anti-La titer group (anti-La>or=100.0). The concentration of serum IgG and the frequency of Sjögren's syndrome in the high anti-La titer group were significantly higher than those in the negative anti-La and low anti-La titer group. Several new aspects of the clinical significance of titrating anti-Ro and anti-La in comparison with SPR have been revealed.
DOI	10.1007/s10165-008-0098-0
PMID	18636224