イセキ　ヒロシ   Iseki Hiroshi   伊関　洋    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   特任顧問
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Sonodynamic Therapy with Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer
掲載誌名	正式名：Frontiers in Pharmacology ISSNコード：16639812
掲載区分	国外
巻・号・頁	10,pp.545
著者・共著者	HORISE Yuki†, MAEDA Masanori, KONISHI Yoshiyuki, OKAMOTO Jun, IKUTA Soko, OKAMOTO yoshiharu , ISHII Hiroshi, YOSHIZAWA YOSHIZAWA,Shin, UMEMURA Shinichiro, UEYAMA Tsuyoshi , TAMANO Satoshi , SOFUNI Atsushi , TAKEMAE Kazuhisa , MASAMUNE Ken, ISEKI Hiroshi, NISHIYAMA Nobuhiro, KATAOKA Kazunori , MURAGAKI Yoshihiro
発行年月	2019/05/21
概要	Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.
DOI	10.3389/fphar.2019.00545