ナガシマ　ヨウジ   Nagashima Youji   長嶋　洋治    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Atypical protein kinase C λ/ι expression is associated with malignancy of oral squamous cell carcinoma.
掲載誌名	正式名：Anticancer research 略　 称：Anticancer Res ISSNコード：02507005/17917530
掲載区分	国外
巻・号・頁	38(11),pp.6291-6297
著者・共著者	Baba J†, Kioi M*, Akimoto K, Nagashma Y, Taguri M, Inayama Y, Aoki I, Ohno S, Mitsudo K, Tohnai I
発行年月	2018/11
概要	BACKGROUND/AIM: Atypical protein kinase C λ/ι (aPKCλ/ι) is a cell polarity-regulator localized in the tight junction and apical membrane in epithelial cells. Previous studies suggested that aPKCλ/ι overexpression and abnormal localization were involved in tumor progression in several cancers. We investigated the relationship between aPKCλ/ι and oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: The correlation between the aPKCλ/ι expression and the clinicopathological parameters in 76 OSCC cases was examined using immunohistochemical analyses. RESULTS: aPKCλ/ι overexpression was observed in 36.8% of cases. aPKCλ/ι expression was more intense in poorly differentiated OSCC and younger patients (<60 years of age). Although expression of aPKCλ/ι was not significantly associated with clinical parameters, the correlation was found between aPKCλ/ι localization and progression-free survival. CONCLUSION: This is the first study to assess the association of aPKCλ/ι expression in OSCC with clinical results. Expression and localization of aPKCλ/ι may be involved in the degree of malignancy in OSCC.
DOI	10.21873/anticanres.12985
PMID	30396949