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ヤナギサワ ナオコ
Yanagisawa Naoko
柳沢 直子 所属 医学部 医学科 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Isolation, selection and characteristics of Lactobacillus paracasei subsp. paracasei F19 |
| 掲載誌名 | 正式名：Microbial Ecology in Health and Disease |
| 掲載区分 | 国外 |
| 巻・号・頁 | 14,pp.4-6 |
| 著者・共著者 | Ljungh A, Lan J, Yanagisawa N |
| 担当区分 | 最終著者 |
| 発行年月 | 2002 |
| 概要 | Lactobacillus strains were isolated from the deep colonic mucus layer of patients without gastrointestinal disease and screened for binding of porcine mucin. Strains exerting high mucin binding were further characterized as to survival ability in the gastrointestinal tract, viz pH stability and bile tolerance. Lactobacillus F19, identified as Lactobacillus paracasei ssp paracasei, bound gastric and bovine mucin, collagen I and III and fibronectin (Fn), and expressed high surface hydrophobicity. It survived exposure to pH 2.5 for 1 h and 20% bile for 2 h, had proteolytic activity and produced bacteriocin(s). It should thus have good possibilities to survive the passage through the gastrointestinal (GI) tract and establish in the GI mucin. Lactobacillus F19 transcribed NF- s B to the nucleus of macrophages, and may thus have immunomodulatory effect. |
| DOI | doi.org/10.1080/089106002760003279 |