ナンケ　ユキ   Nanke Yuki   南家　由紀    所属   看護学部 看護学科    職種   教授
論文種別	総説
言語種別	日本語
査読の有無	査読あり
表題	Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis.
掲載誌名	正式名：Japanese journal of clinical immunology 略　 称：Nihon Rinsho Meneki Gakkai Kaishi ISSNコード：(1349-7413)0911-4300(Linking)
掲載区分	国内
巻・号・頁	32(6),466-71頁
著者・共著者	Kotake Shigeru, Yago Toru, Kawamoto Manabu, Nanke Yuki
発行年月	2009/12
概要	Synovial tissues of patients with rheumatoid arthritis (RA) include factors regulating bone resorption, such as receptor activator NF-kappaB ligand (RANKL), TNF-alpha, IL-6, IL-17, and IFN-gamma. However, in addition to these cytokines, other factors expressed in synovial tissues may play a role in regulating bone resorption. In 2009, we demonstrated that novel peptides from T-cell leukemia translocation-associated gene (TCTA) protein expressed in synovial tissues from patients with RA inhibit human osteoclastogenesis, preventing cellular fusion via the interaction between TCTA protein and a putative counterpart molecule. Only a few studies on the role of TCTA protein have been reported, including our report published in 2009. In the current review paper, we summarized papers on TCTA protein before 2009 and our recent findings.
DOI	10.2177/jsci.32.466
PMID	20046013