ナンケ　ユキ   Nanke Yuki   南家　由紀    所属   看護学部 看護学科    職種   教授
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis.
掲載誌名	正式名：Journal of biomedicine & biotechnology 略　 称：J Biomed Biotechnol ISSNコード：(1110-7251)1110-7243(Linking)
掲載区分	国外
巻・号・頁	2012,pp.675317
著者・共著者	Kotake Shigeru, Yago Toru, Kawamoto Manabu, Nanke Yuki
発行年月	2012
概要	Synovial tissues of patients with rheumatoid arthritis (RA) include factors regulating bone resorption, such as receptor activator NF-κB ligand (RANKL), TNF-α, IL-6, IL-17, and IFN-γ. However, in addition to these cytokines, other factors expressed in synovial tissues may play a role in regulating bone resorption. In 2009, we demonstrated that novel peptides from T-cell leukemia translocation-associated gene (TCTA) protein expressed in synovial tissues from patients with RA inhibit human osteoclastogenesis, preventing cellular fusion via the interaction between TCTA protein and a putative counterpart molecule. Only a few studies on the role of TCTA protein have been reported. Genomic Southern blots demonstrated a reduced TCTA signal in three of four small cell lung cancer cell lines, suggesting the loss of one of the two copies of the gene. In the current paper, we reviewed the roles of TCTA protein in lung cancer cell lines and human osteoclastogenesis.
DOI	10.1155/2012/675317
PMID	22174563