ヤマナカ　ヒサシ   Yamanaka Hisashi   山中　寿    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Progressive appearance of overlap syndrome together with autoantibodies in a patient with fatal thrombotic microangiopathy.
掲載誌名	正式名：The American journal of the medical sciences 略　 称：Am J Med Sci ISSNコード：(0002-9629)0002-9629(Linking)
掲載区分	国外
巻・号・頁	320(5),pp.348-51
著者・共著者	Nanke Y, Akama H, Yamanaka H, Hara M, Kamatani N
発行年月	2000/11
概要	We describe an extraordinary patient with overlap syndrome (systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis) having positive autoantibodies against Sm, double stranded DNA, DNA topoisomerase I, and centromere, together with rheumatoid factor. The patient had multiple organ involvement resulting from thrombotic microangiopathy that mimicked so-called normotensive scleroderma renal crisis, and died mainly of massive pulmonary hemorrhage caused by thrombotic thrombocytopenic purpura. The clinical presentations of the case support the concept of strong associations between disease-specific autoantibodies and clinical features.
DOI	10.1097/00000441-200011000-00010
PMID	11093690