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ヤマウチ カヅヨ
YAMAUCHI Kadzuyo
山内 かづ代 所属 医学部 医学科 職種 評議員 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | TNF-alpha in nucleus pulposus induces sensory nerve growth: a study of the mechanism of discogenic low back pain using TNF-alpha-deficient mice. |
| 掲載誌名 | 正式名：Spine 略 称：Spine (Phila Pa 1976) ISSNコード：(1528-1159)0362-2436(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 33(14),pp.1542-6 |
| 著者・共著者 | Hayashi Shinu, Taira Akiko, Inoue Gen, Koshi Takana, Ito Toshinori, Yamashita Masaomi, Yamauchi Kazuyo, Suzuki Munetaka, Takahashi Kazuhisa, Ohtori Seiji |
| 発行年月 | 2008/06 |
| 概要 | Within the set of fluoro-gold-labeled neurons, 10% were positive for GAP43 in sham-operated animals, 22% positive in the TNF-deficient NP group, and 38% positive in the wild-type NP group. These intergroup differences in the percentage of GAP43-positive neurons were statistically significant (sham vs. TNF-deficient NP group: P = 0.009; TNF-deficient NP group vs wild-type NP group: P = 0.026). CONCLUSION.: The percentage of fluoro-gold-labeled GAP43-immunoreactive neurons significantly increased after injections of NP harvested from both mouse types. Furthermore, the percentage of GAP43-immunoreactive neurons was significantly higher in mice receiving wild-type NP compared with mice receiving TNF-deficient NP. These findings suggest that TNF-alpha acts as an inducer of axonal growth into degenerated discs, as evidenced by decreased GAP-43 immunoreactivity in mice receiving TNF-deficient NP injections and even lower GAP-43 immunoreactivity in control mice receiving NP-free fluoro-gold injections. |
| DOI | 10.1097/BRS.0b013e318178e5ea |
| PMID | 18552668 |