ヤマウチ　カヅヨ   YAMAUCHI Kadzuyo   山内　かづ代    所属   医学部 医学科    職種   評議員
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Risedronate decreases bone resorption and improves low back pain in postmenopausal osteoporosis patients without vertebral fractures.
掲載誌名	正式名：Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 略　 称：J Clin Neurosci ISSNコード：(1532-2653)0967-5868(Linking)
掲載区分	国外
巻・号・頁	17(2),pp.209-13
著者・共著者	Ohtori Seiji, Akazawa Tsutomu, Murata Yasuaki, Kinoshita Tomoaki, Yamashita Masaomi, Nakagawa Koichi, Inoue Gen, Nakamura Junichi, Orita Sumihisa, Ochiai Nobuyasu, Kishida Shunji, Takaso Masashi, Eguchi Yawara, Yamauchi Kazuyo, Suzuki Munetaka, Aoki Yasuchika, Takahashi Kazuhisa
発行年月	2010/02
概要	Elderly postmenopausal women who have osteoporosis sometimes experience low back pain, however, the relationship between low back pain and osteoporosis in the absence of vertebral fractures remains unclear. We examined the relationship between bone mineral density (BMD), bone resorption and low back pain in elderly female patients who did not have osteoporotic vertebral fractures. The average BMD was 0.675 g/cm(2) when assessed by dual-energy X-ray absorptiometry (DEXA). Patients were excluded from the study if they had vertebral fractures revealed by radiography, CT scans or MRI. Bisphosphonate (risedronate) was administered for 4 months. The visual analogue scale (VAS) pain score, Roland Morris Disability Questionnaire (RDQ), Short Form-36 (SF-36) questionnaire, BMD and N-terminal telopeptide of type I collagen (NTx; a marker for bone resorption) were examined before and after treatment. DEXA did not increase significantly, but serum and urinary NTx were decreased (-51.4% and -62.0%, respectively) after 4 months of risedronate treatment (p<0.01). The assessment was repeated using the VAS score, RDQ and SF-36, which revealed an improvement after risedronate treatment (p<0.01). A decrease in serum and urinary NTx was associated with improvement of low back pain, suggesting that despite the absence of vertebral fractures, bone resorption due to osteoporosis may cause low back pain.
DOI	10.1016/j.jocn.2009.06.013
PMID	20044258