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ヤマウチ カヅヨ
YAMAUCHI Kadzuyo
山内 かづ代 所属 医学部 医学科 職種 評議員 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Dose Optimization for Single Intradiscal Administration of the Tumor Necrosis Factor-α Inhibitor, Etanercept, in Rat Disc Injury Models. |
| 掲載誌名 | 正式名：Asian spine journal 略 称：Asian Spine J ISSNコード：(1976-1902)1976-1902(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 10(4),pp.619-23 |
| 著者・共著者 | Inage Kazuhide, Orita Sumihisa, Yamauchi Kazuyo, Suzuki Takane, Suzuki Miyako, Sakuma Yoshihiro, Kubota Go, Oikawa Yasuhiro, Sainoh Takeshi, Sato Jun, Fujimoto Kazuki, Shiga Yasuhiro, Abe Koki, Kanamoto Hirohito, Inoue Masahiro, Kinoshita Hideyuki, Takahashi Kazuhisa, Ohtori Seiji |
| 発行年月 | 2016/08 |
| 概要 | When a low dose of the TNF-α inhibitor (10 µg of etanercept) was directly administered to the rat intervertebral disc in the rat model of degenerative intervertebral disc from injury, no suppressive effect on the pain-related peptide expression was observed. However, when a higher dose of etanercept (100 µg and 1,000 µg) was administered, the pain-related peptide expression was suppressed in a dose-dependent manner. |
| DOI | 10.4184/asj.2016.10.4.619 |
| PMID | 27559439 |