ヤマウチ　カヅヨ   YAMAUCHI Kadzuyo   山内　かづ代    所属   医学部 医学科    職種   評議員
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study.
掲載誌名	正式名：Pain research & management 略　 称：Pain Res Manag ISSNコード：(1918-1523)1203-6765(Linking)
掲載区分	国外
巻・号・頁	2016,pp.5079675
著者・共著者	Orita Sumihisa, Yamashita Masaomi, Eguchi Yawara, Suzuki Miyako, Inoue Gen, Miyagi Masayuki, Watanabe Tomoko, Ozawa Tomoyuki, Kamoda Hiroto, Ishikawa Tetsuhiro, Aoki Yasuchika, Ito Toshinori, Kubota Go, Suzuki Munetaka, Yamauchi Kazuyo, Hanaoka Eiji, Sakuma Yoshihiro, Shimbo Jun, Oikawa Yasuhiro, Suzuki Takane, Takahashi Kazuhisa, Ohtori Seiji
発行年月	2016
概要	We investigated the efficacy of pregabalin (PGB) for neuropathic leg pain in lumbar spinal stenosis (LSS) patients with disturbed activities of daily living (ADL)/quality of life (QOL) in a prospective observational study. Subjects were a total of 104 LSS patients with neuropathic pain (NeP) in leg and neurological intermittent claudication (IMC) refractory to nonsteroidal anti-inflammatory drugs (NSAIDs) for at least a month. NeP was identified using screening tool, Pain DETECT questionnaire. Visual analog scale (VAS) scores and responses to the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) were assessed before and 6 weeks after PGB treatment initiation. Changes in IMC distance and adverse events were also recorded. PGB significantly improved their VAS scores for pain and sleep quality (P < 0.001). With respect to JOABPEQ, significant improvements were observed with regard to the following dimensions: pain-related disorders (P < 0.01), lumbar spine dysfunction (P = 0.031), gait disturbance (P = 0.028), and psychological disorders (P = 0.014). The IMC distance showed an improvement tendency after PGB treatment, albeit with no significance (P = 0.063). Minor adverse events such as dizziness were observed. PGB can be effective for neuropathic leg pain refractory to NSAIDs in LSS patients, resulting in not only pain control but also improving lower back pain-related ADL/QOL scores.
DOI	10.1155/2016/5079675
PMID	27445615