ヒロタ　ケイコ   Keiko HIROTA   廣田　恵子    所属   医学部 医学科    職種   講師
論文種別	総説
言語種別	英語
査読の有無	査読なし
表題	Transcriptional regulation of energy metabolism in the liver.
掲載誌名	正式名：Journal of receptor and signal transduction research 略　 称：J Recept Signal Transduct Res ISSNコード：10799893
掲載区分	国外
巻・号・頁	30(6),pp.403
著者・共著者	HIROTA Keiko†, FUKAMIZU Akiyoshi*
担当区分	筆頭著者
発行年月	2010/12
概要	Living organisms maintain energy homeostasis by constantly adjusting internal metabolic activities in response to nutritional states. Energy metabolism is regulated by the quality and quantity of the enzymes that catalyze metabolic reactions. Recruitment and regulation of enzymes responsible for transcriptional control, among others, play an important role in this process. Located downstream from intracellular signaling cascades, transcription factors receive information signals from multiple sources. Their primary function is to integrate and interpret this information in terms of transcriptional output. It was recently suggested that signal content is converted via post-transcriptional modifications of the transcription factors. Many studies have shown that multiple signaling pathways converge on single transcription factors. This review discusses the post-translational modifications of transcription factors involved in the regulation of glucose metabolism, as well as the signaling networks in which they play a role.
DOI	10.3109/10799893.2010.509730.