ナカヤマ　ヒサコ   Hisako Nakayama   中山　寿子    所属   医学部 医学科    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive.
掲載誌名	正式名：Cell Reports 略　 称：Cell Rep ISSNコード：22111247
掲載区分	国外
巻・号・頁	16(4),pp.994-1004
著者・共著者	MATSUMOTO-MAKIDONO Yoshiko†, NAKAYAMA Hisako, YAMASAKI Miwako, MIYAZAKI Taisuke, WATANABE Masahiko, KANO Masanobu, SAKIMURA Kenji, HASHIMOTO Kouichi*
担当区分	2nd著者
発行年月	2016/07
概要	Some neurons have the ability to enhance output voltage to input current with a preferred frequency, which is called resonance. Resonance is thought to be a basis for membrane potential oscillation. Although ion channels responsible for resonance have been reported, the precise mechanisms by which these channels work remain poorly understood. We have found that resonance is reduced but clearly present in the inferior olivary neurons of Cav3.1 T-type voltage-dependent Ca(2+) channel knockout (KO) mice. The activation of Cav3.1 channels is strongly membrane potential dependent, but less frequency dependent. Residual resonance in Cav3.1 KO mice is abolished by a hyper-polarization-activated cyclic nucleotide-gated (HCN) channel blocker, ZD7288, and is partially suppressed by voltage-dependent K(+) channel blockers. Resonance is inhibited by ZD7288 in wild-type mice and impaired in HCN1 KO mice, suggesting that the HCN1 channel is essential for resonance. The ZD7288-sensitive current is nearly sinusoidal and strongly frequency dependent. These results suggest that Cav3.1 and HCN1 channels act as amplifying and resonating conductances, respectively.
DOI	10.1016/j.celrep.2016.06.053.
PMID	27425615