ナカヤマ　ヒサコ   Hisako Nakayama   中山　寿子    所属   医学部 医学科    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism.
掲載誌名	正式名：Nature Communications 略　 称：Nat Commun ISSNコード：20411723
掲載区分	国外
巻・号・頁	5,pp.5586
著者・共著者	PIOCHON Claire†, KLOTH Alexander D, GRASSELLI Giorgio, TITLEY HEATHER K, NAKAYAMA Hisako, HASHIMOTO Kouichi, WAN Vivian, SIMMONS Dana H, EISSA Tahra, NAKATANI Jin, CHERSKOV Adriana, MIYAZAKI Taisuke, WATANABE Masahiko, TAKUMI Toru, KANO Masanobu, WANG Samuel S-H, HANSEL Christian*
発行年月	2014/11
概要	A common feature of autism spectrum disorder (ASD) is the impairment of motor control and learning, occurring in a majority of children with autism, consistent with perturbation in cerebellar function. Here we report alterations in motor behaviour and cerebellar synaptic plasticity in a mouse model (patDp/+) for the human 15q11-13 duplication, one of the most frequently observed genetic aberrations in autism. These mice show ASD-resembling social behaviour deficits. We find that in patDp/+ mice delay eyeblink conditioning--a form of cerebellum-dependent motor learning--is impaired, and observe deregulation of a putative cellular mechanism for motor learning, long-term depression (LTD) at parallel fibre-Purkinje cell synapses. Moreover, developmental elimination of surplus climbing fibres--a model for activity-dependent synaptic pruning--is impaired. These findings point to deficits in synaptic plasticity and pruning as potential causes for motor problems and abnormal circuit development in autism.
DOI	10.1038/ncomms6586
PMID	25418414