ナカムラ　シンイチ   Nakamura Shin'ichi   中村　真一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	症例報告
言語種別	英語
査読の有無	査読なし
表題	Development and Improvement of Simple Colonic Mucosal Ulcer during Treatment of Severe Ulcerative Colitis with Tacrolimus.
掲載誌名	正式名：Case reports in gastroenterology 略　 称：Case Rep Gastroenterol ISSNコード：(1662-0631)1662-0631(Linking)
掲載区分	国外
巻・号・頁	11(1),pp.168-177
著者・共著者	ITO Ayumi†, IIZUKA Bunei, OMORI Teppei, NAKAMRA Shinichi, TOKUSHIGE Katsutoshi
発行年月	2017
概要	Diarrhea, melena, and lower abdominal pain developed in a male in his 20s and colonoscopy showed pancolitis-type severe ulcerative colitis (UC). Treatment was initiated with 4,000 mg of 5-aminosalicylic acid and 60 mg/day of prednisolone, but the symptoms and inflammatory reaction worsened with prednisolone dose reduction. Tacrolimus was added to the treatment, which subsequently induced remission. Serial colonoscopies during the treatment showed improvement in ulcer and mucosal edema throughout the entire large intestine, but a new solitary round ulcer appeared at the end of the ileum. Since no signs of Behçet's disease were noted, it was considered as a simple ulcer, a complication of UC. Tacrolimus treatment was continued based on continued improvement in clinical features and colonic mucosa, excluding the end of the ileum. Colonoscopy at 6 months after initiation of tacrolimus showed healing of the large intestinal mucosa, although mild congestion was still noted. The solitary round ulcer at the end of the ileum improved to a small erosion. We report the improvement of a simple ulcer that developed during tacrolimus treatment.
DOI	10.1159/000456605
PMID	28611570