ハナフサ　ノリオ   Hanafusa Norio   花房　規男    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Safety and efficacy of cell-free and concentrated ascites reinfusion therapy (CART) in refractory ascites: Post-marketing surveillance results.
掲載誌名	正式名：PloS one 略　 称：PLoS One ISSNコード：(1932-6203)1932-6203(Linking)
掲載区分	国外
巻・号・頁	12(5),pp.e0177303
著者・共著者	Hanafusa Norio, Isoai Ayako, Ishihara Tomoaki, Inoue Tetsuya, Ishitani Ken, Utsugisawa Taiju, Yamaka Toshihiko, Ito Tetsuya, Sugiyama Hiroshi, Arakawa Atsushi, Yamada Yosuke, Itano Yasuo, Onodera Hirokazu, Kobayashi Ryosuke, Torii Naoko, Numata Toyoko, Kashiwabara Taihei, Matsuno Yoshihiro, Kato Michio
発行年月	2017/05
概要	We performed post-marketing surveillance to evaluate the safety and efficacy of cell-free and concentrated ascites reinfusion therapy (CART). In total, 356 CART sessions in 147 patients at 22 centers were performed. The most common primary disease was cancer (128 cases, 300 sessions). Mean amount of ascites collected was 3.7 L, and mean concentration ratio was 9.2. Mean amount of reinfused protein was 67.8 g (recovery rate, 72.0%). Performance status, dietary intake, urine volume, body weight and abdominal circumference were significantly improved after CART. Body temperature increased significantly, by 0.3°C on average. Concomitant steroids and/or NSAIDs use before reinfusion was significantly and negatively associated with increases in body temperature. Most adverse events were fever and chills. This study examined a large number of patients compared with previous studies, and showed that CART is an effective and relatively safe treatment for refractory ascites, such as malignant ascites.
DOI	10.1371/journal.pone.0177303
PMID	28510606