ウチガタ　ヤスコ   Uchigata Yasuko   内潟　安子    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤嘱託
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Renal Function after Intravitreal Administration of Vascular Endothelial Growth Factor Inhibitors in Patients with Diabetes and Chronic Kidney Disease.
掲載誌名	正式名：Journal of diabetes investigation 略　 称：J Diabetes Investig ISSNコード：(2040-1124)2040-1116(Linking)
掲載区分	国外
巻・号・頁	pp.29108104
著者・共著者	Kameda Yusuke, Babazono Tetsuya, Uchigata Yasuko, Kitano Shigehiko
発行年月	2017/11
概要	This study aimed to determine whether intravitreal administration of vascular endothelial growth factor inhibitors is associated with deterioration of renal function, as seen with systemic administration, in patients with diabetes and chronic kidney disease. Estimated glomerular filtration rates before and after 160 intravitreal injections of vascular endothelial growth factor inhibitors (aflibercept, bevacizumab, or ranibizumab) were compared in 69 patients with diabetes and with a baseline estimated glomerular filtration rate <60 mL/min/1.73 m2 . We also determined the incidence of acute kidney injury. The data showed no significant difference in the estimated glomerular filtration rate before and after vascular endothelial growth factor inhibitor administration in all patients and in patient subgroups based on each inhibitor. Furthermore, no episodes of acute kidney injury occurred. In conclusion, intravitreal administration of vascular endothelial growth factor inhibitors is unlikely to be associated with a deterioration of renal function in patients with diabetes and chronic kidney disease. This article is protected by copyright. All rights reserved.
DOI	10.1111/jdi.12771
PMID	29108104