タナベ　ケンジ   Tanabe Kenji   田邊　賢司    所属   研究施設 研究施設    職種   准教授
論文種別	総説
言語種別	英語
査読の有無	査読あり
招待の有無	招待あり
表題	Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors.
掲載誌名	正式名：International journal of molecular sciences 略　 称：Int J Mol Sci ISSNコード：(1422-0067)1422-0067(Linking)
掲載区分	国外
巻・号・頁	18(12),pp.2508
著者・共著者	Tanabe Kenji
担当区分	筆頭著者,責任著者
発行年月	2017/11
概要	Microtubule-targeting agents are widely used as clinical drugs in the treatment of cancer. However, some kinase inhibitors can also disrupt microtubule organization by directly binding to tubulin. These unexpected effects may result in a plethora of harmful events and/or a misinterpretation of the experimental results. Thus, further studies are needed to understand these dual inhibitors. In this review, I discuss the roles of dual inhibitors of kinase activity and microtubule function as well as describe the properties underlining their dual roles. Since both kinase and microtubule inhibitors cause cell toxicity and cell cycle arrest, it is difficult to determine which inhibitor is responsible for each phenotype. A discrimination of cell cycle arrest at G0/G1 or G2/M and/or image analyses of cellular phenotype may eventually lead to new insights on drug duality. Because of the indispensable roles of microtubules in mitosis and vesicle transport, I propose a simple and easy method to identify microtubule depolymerizing compounds.
DOI	10.3390/ijms18122508
PMID	29168788