ヨシダ　ケイタ   Yoshida Keita   吉田　慶太    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Nonreproductive role of gonadotropin-releasing hormone in the control of ascidian metamorphosis.
掲載誌名	正式名：Developmental dynamics : an official publication of the American Association of Anatomists 略　 称：Dev Dyn ISSNコード：1097-0177(Electronic)1058-8388(Linking)
掲載区分	国外
巻・号・頁	243(12),pp.1524-35
著者・共著者	Kamiya Chisato†, Ohta Naoyuki, Ogura Yosuke, Yoshida Keita, Horie Takeo, Kusakabe Takehiro G, Satake Honoo, Sasakura Yasunori*
発行年月	2014/12
概要	BACKGROUND:Gonadotropin-releasing hormones (GnRHs) are neuropeptides that play central roles in the reproduction of vertebrates. In the ascidian Ciona intestinalis, GnRHs and their receptors are expressed in the nervous systems at the larval stage, when animals are not yet capable of reproduction, suggesting that the hormones have non-reproductive roles.RESULTS:We showed that GnRHs in Ciona are involved in the animal's metamorphosis by regulating tail absorption and adult organ growth. Absorption of the larval tail and growth of the adult organs are two major events in the metamorphosis of ascidians. When larvae were treated with GnRHs, they completed tail absorption more frequently than control larvae. cAMP was suggested to be a second messenger for the induction of tail absorption by GnRHs. tGnRH-3 and tGnRH-5 (theRESULTS:"RESULTS:tRESULTS:"RESULTS:indicatesRESULTS:"RESULTS:tunicateRESULTS:"RESULTS:) inhibited the growth of adult organs by arresting cell cycle progression in parallel with the promotion of tail absorption.CONCLUSIONS:This study provides new insights into the molecular mechanisms of ascidian metamorphosis conducted by non-reproductive GnRHs.
DOI	02/dvdy.24176
文献番号	25130398