ヨシダ　ケイタ   Yoshida Keita   吉田　慶太    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Hox-mediated endodermal identity patterns pharyngeal muscle formation in the chordate pharynx.
掲載誌名	正式名：Development (Cambridge, England) 略　 称：Development ISSNコード：1477-9129(Electronic)0950-1991(Linking)
掲載区分	国外
巻・号・頁	144(9),pp.1629-1634
著者・共著者	Yoshida Keita†*, Nakahata Azusa, Treen Nicholas, Sakuma Tetsushi, Yamamoto Takashi, Sasakura Yasunori
担当区分	筆頭著者,責任著者
発行年月	2017/05
概要	The chordate pharynx, possessing gill slits and the endostyle, is a complex of multiple tissues that are highly organized along the anterior-posterior (AP) axis. Although Hox genes show AP coordinated expression in the pharyngeal endoderm, tissue-specific roles of these factors for establishing the regional identities within this tissue have not been demonstrated. Here, we show that Hox1 is essential for the establishment of AP axial identity of the endostyle, a major structure of the pharyngeal endoderm, in the ascidian Ciona intestinalis We found that knockout of Hox1 causes posterior-to-anterior transformation of the endostyle identity, and that Hox1 represses Otx expression and anterior identity, and vice versa. Furthermore, alteration of the regional identity of the endostyle disrupts the formation of body wall muscles, suggesting that the endodermal axial identity is essential for coordinated pharyngeal development. Our results demonstrate an essential role of Hox genes in establishment of the AP regional identity in the pharyngeal endoderm and reveal crosstalk between endoderm and mesoderm during development of chordate pharynx.
DOI	10.1242/dev.144436
文献番号	28289133