オカモト　ヒロシ   Okamoto Hiroshi   岡本　完    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The serum concentration of infliximab in cases of autologous blood donation for patients with rheumatoid arthritis.
掲載誌名	正式名：Modern rheumatology 略　 称：Mod Rheumatol ISSNコード：(1439-7595)1439-7595(Linking)
巻・号・頁	17(1),pp.24-27
著者・共著者	Mochizuki Takeshi, Momohara Shigeki, Ikari Katsunori, Okamoto Hiroshi, Kobayashi Shu, Tsukahara So, Iwamoto Takuji, Kawamura Koichiro, Saito Seiji, Tomatsu Taisuke
発行年月	2007
概要	Our aim was to determine whether the use of infliximab for rheumatoid arthritis (RA) patients is associated with an increased rate of postoperative complications. In this study we evaluated the serum concentration of infliximab to study the influence of autologous blood donation (AB donation) in patients who were administered infliximab and underwent total knee replacement (TKR). We examined five RA patients. Infliximab combined with methotrexate was administered at 3 mg/kg every 8 weeks for all patients. We carried out the TKR operation in the middle of the 8-week interval in which infliximab was administered. The AB donation consisted of 400 ml pooled AB drawn at one point 2 weeks following the final administration of infliximab. Serum infliximab levels were measured using an enzyme-linked immunosorbent assay. Mean serum infliximab levels were 5.46 +/- 5.62 microg/ml 2 weeks after the final administration of infliximab, 2.02 +/- 1.66 microg/ml just before the operation, and 1.48 +/- 1.31 microg/ml 1 day post operation. Moreover, the mean serum level in an autologous blood bag sampled just before AB donation was 5.02 +/- 4.79 microg/ml. This study indicated the serum level of infliximab in the stored blood remained at almost the same level as the collected autologous blood. However, even after autotransfusion those levels were decreased compared with levels measured just before the operation. Therefore, we conclude that there is little influence of AB donation on the risks of infliximab.
DOI	10.1007/s10165-006-0539-6
PMID	17278018