シミズ　タツヤ   Shimizu Tatsuya   清水　達也    所属   医学研究科 医学研究科 (医学部医学科をご参照ください)    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Cell delivery in regenerative medicine: the cell sheet engineering approach.
掲載誌名	正式名：Journal of controlled release : official journal of the Controlled Release Society 略　 称：J Control Release ISSNコード：(0168-3659)0168-3659(Linking)
掲載区分	国外
巻・号・頁	116(2),pp.193-203
著者・共著者	YANG Joseph†, YAMATO Masayuki, NISHIDA Kohji, OHKI Takeshi, KANZAKI Masato, SEKINE Hidekazu, SHIMIZU Tatsuya, OKANO Teruo*
発行年月	2006/11
概要	Recently, cell-based therapies have developed as a foundation for regenerative medicine. General approaches for cell delivery have thus far involved the use of direct injection of single cell suspensions into the target tissues. Additionally, tissue engineering with the general paradigm of seeding cells into biodegradable scaffolds has also evolved as a method for the reconstruction of various tissues and organs. With success in clinical trials, regenerative therapies using these approaches have therefore garnered significant interest and attention. As a novel alternative, we have developed cell sheet engineering using temperature-responsive culture dishes, which allows for the non-invasive harvest of cultured cells as intact sheets along with their deposited extracellular matrix. Using this approach, cell sheets can be directly transplanted to host tissues without the use of scaffolding or carrier materials, or used to create in vitro tissue constructs via the layering of individual cell sheets. In addition to simple transplantation, cell sheet engineered constructs have also been applied for alternative therapies such as endoscopic transplantation, combinatorial tissue reconstruction, and polysurgery to overcome limitations of regenerative therapies and cell delivery using conventional approaches.
DOI	10.1016/j.jconrel.2006.06.022
PMID	16890320