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ムラガキ ヨシヒロ
Muragaki Yoshihiro
村垣 善浩 所属 医学部 医学科（東京女子医科大学病院） 職種 客員教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | High Expression of Glypican-1 Predicts Dissemination and Poor Prognosis in Glioblastomas. |
| 掲載誌名 | 正式名：World neurosurgery 略 称：World Neurosurg ISSNコード：18788750 |
| 掲載区分 | 国外 |
| 巻・号・頁 | (105),pp.282-288 |
| 著者・共著者 | SAITO Taiichi†, SUGIYAMA Kazuhiko , HAMA Seiji , YAMASAKI Fumiyuki, TAKAYASU Takeshi , NOSAKA Ryo , ONISHI Shumpei, MURAGAKI Yoshihiro, KAWAMATA Takakazu, KURISU Kaoru |
| 発行年月 | 2017/09 |
| 概要 | OBJECTIVE:Glioblastoma (GBM) relapses locally or in a disseminated pattern, and is highly resistant to chemo-radiotherapy. Although dissemination is associated with poor prognosis for GBM patients, the clinico-pathological factors that promote dissemination have not been elucidated. Glypican-1 (GPC-1) is a heparin sulfate proteoglycan that is attached to the extracytoplasmic surface of the cell membrane and regulates cell motility. The aim of this study was to determine whether GPC-1 expression correlated with GBM dissemination and patient prognosis.METHODS:GPC-1 expression was examined by immunohistochemistry in 53 patients with GBM who received radiotherapy and temozolomide (TMZ) treatment. We assessed the relationship between dissemination and clinico-pathological factors, including GPC-1 expression. Additionally, we evaluated the relationship between GPC-1 expression and overall survival (OS) by uni- and multivariate analyses of a range of clinico-pathological factors, including age, Karnofsky Performance Status (KPS), extent of resection, and O6-methylguanine-DNA methyltransferase (MGMT) status.RESULTS:Logistic regression analysis revealed that GPC-1 expression correlated with dissemination (P = 0.0116). Log-rank tests revealed that age, KPS, extent of resection, MGMT status, dissemination (P = 0.0008) and GPC-1 expression (P = 0.0011) were significantly correlated with OS. Multivariate analysis indicated that age, MGMT status, and GPC-1 expression were significantly correlated with OS. GPC-1 expression had the highest hazard ratio (2.392) among all regressors.CONCLUSIONS:GPC-1 expression significantly correlated with OS in GBM patients who received radiotherapy and TMZ treatment. GPC-1 expression can help predict the occurrence of dissemination and shorter OS in GBM patients. |
| DOI | 10.1016/j.wneu.2017.05.165 |
| PMID | 28602885 |